SIS, SSS, and TPV were greater in PsA patients than controls ( P = 0.003, P = 0.001, and P ≤ 0.001, respectively). More PsA patients had mixed plaques, and mixed plaque volume was higher than in controls ( P
Book Title: Higher Coronary Plaque Burden in Psoriatic Arthritis Is Independent of Metabolic Syndrome and Associated With Underlying Disease Severity
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Published on 2018 by
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Book is About: Psoriasis
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Abstract : Objective: To examine the effect of metabolic syndrome and psoriatic disease–related variables on coronary plaque burden in psoriatic arthritis (PsA) patients. Methods: Fifty PsA patients without symptoms of coronary artery disease (CAD) (25 with metabolic syndrome and 25 without metabolic syndrome) and 50 age‐ and sex‐matched controls underwent 64‐slice coronary computed tomography angiography. Plaque localization, segment involvement score (SIS), segment stenosis score (SSS), and total plaque volume (TPV) were calculated. Plaques were classified as calcified, mixed, or noncalcified. Kruskal‐Wallis test, rank correlations, and linear regression analyses were used to study the relationship between PsA, metabolic syndrome, and plaque burden. Results: Plaques were found in 76% of PsA patients versus 44% of controls ( P = 0.001), and a higher proportion of patients with PsA had affected coronary vessels ( P = 0.007). SIS, SSS, and TPV were greater in PsA patients than controls ( P = 0.003, P = 0.001, and P ≤ 0.001, respectively). More PsA patients had mixed plaques, and mixed plaque volume was higher than in controls ( P
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