Treatment comparisons with placebo included data from three studies, whereas etanercept comparisons were based on two studies. Results: Ixekizumab treatment was superior to placebo ( P
Book Title: Ixekizumab Treatment for Psoriasis: Integrated Efficacy Analysis of Three Double‐blinded, Controlled Studies (UNCOVER‐1, UNCOVER‐2, UNCOVER‐3).
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Book is About: Psoriasis
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Background: Ixekizumab, a high‐affinity monoclonal antibody that selectively targets interleukin (IL)‐17A, is approved for the treatment of moderate‐to‐severe psoriasis. Objectives: This analysis represents an overview of the efficacy outcomes from three phase III psoriasis studies. Methods: Data were integrated from the 12‐week induction period of three studies in which patients received ixekizumab 80mg every 2weeks (IXE Q2W; n = 1169) or every 4weeks (IXE Q4W; n = 1165) after an initial 160‐mg dose for both; etanercept (50mg biweekly; n = 740; two studies) or placebo ( n = 792). The coprimary end points were the percentages of patients with response of static Physician's Global Assessment (sPGA; score 0 or 1) and ≥ 75% improvement in baseline Psoriasis Area and Severity Index (PASI 75) at week 12. Response rates were compared between treatments using the Cochran–Mantel–Haenszel test stratified by study. Treatment comparisons with placebo included data from three studies, whereas etanercept comparisons were based on two studies. Results: Ixekizumab treatment was superior to placebo ( P
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